Characteristics of Interval Colorectal Cancer: A Canadian Retrospective Population-Level Analysis from Newfoundland and Labrador.

Interval colorectal cancers (I-CRCs) arise during the interval time period between scheduled colonoscopies. Predicting which patients are at risk of I-CRCs remains an elusive undertaking, but evidence would suggest that most I-CRCs arise from lesions missed on index endoscopy. The procedural factors that lead to missed lesions are numerous and lack consensus in the literature. In Canada, the province of Newfoundland and Labrador has the highest incidence of CRCs. In this study our aim was to examine I-CRCs (3-60 months after last colonoscopy) in NL through a population-level analysis covering 67% of the province from 2001-2018. We estimated the I-CRC rate to be up to 9.3%. Median age of I-CRC diagnosis was 67.1 years with an interval time of 2.9 years. About 57% of these tumors occurred proximal to the splenic flexure, with 53% presenting as local disease. No temporal differences were observed in interval time or tumor distribution. On univariate and multivariable logistical regression, risk of right-sided I-CRC did not correlate to the index colonoscopy indication, bowel preparation quality, size of largest polyp removed, colonoscopy completion rate, or stage at presentation. Improvements in synoptic reporting utilization and national registries are needed to identity risk factors and reduce I-CRC frequency.

Development and Evaluation of a 3D-Printed Adult Proximal Tibia Model for Simulation Training in Intraosseous Access.

Intraosseous infusion remains an underutilized technique for obtaining vascular access in adults, despite its potentially life-saving benefits in trauma patients and those presenting to the emergency department. There is a scarcity of cost-effective, anatomically correct trainers to improve physician confidence and competency in this skill. The purpose of this report is to describe the development and evaluation of a three-dimensional (3D) printed Adult Proximal Intraosseous (IO) Tibia task trainer for simulation-based medical education. The proposed trainer was designed by combining open-source models of a human skeleton and a lower leg surface scan in Blender (Blender Foundation - www.blender.org) and manipulating them further using a JavaScript program. Polylactic acid was used to simulate bone while cured silicone moulds were used to replicate skin and soft tissue. Two trainers were produced and tested by 15 rural family medicine residents, six rural emergency medicine physicians, and six registered nurses. Participants evaluated the realism of the trainer and its efficacy as a training tool through a structured survey. The trainer received overall positive feedback from all participants, and most participants felt that no improvements were required to use the trainer for medical education. Notable suggestions for improvement included adding an infusion component, increasing the size of the tibial tubercle for better landmarking, and creating a variety of sizes for different patient body types. Residents and emergency medicine physicians practising in rural Newfoundland and Labrador found the 3D-printed trainer to be a practical tool for practising intraosseous technique. The outcome of this report supports the use of this cost-effective trainer for simulation-based medical education.